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epidemiology of uterine fibroids

Correlation of low serum vitamin-D with uterine leiomyoma: a systematic review and meta-analysis. Further observational data from large well‐conducted prospective studies on the occurrence of both symptomatic and asymptomatic UFs will therefore prove invaluable in improving our understanding of the aetiology of this often debilitating disease, and may thus facilitate progress in its management. Characterization of the role of Activator Protein 1 signaling pathway on extracellular matrix deposition in uterine leiomyoma. Clipboard, Search History, and several other advanced features are temporarily unavailable. Intra-abdominal haemorrhage from uterine fibroids: a systematic review of the literature. Narasimman M, De Bedout V, Castillo DE, Miteva MI. They are found in approximately 80% of hysterectomy specimens 2. Although uterine leiomyomata (fibroids) have been the leading indication for hysterectomy in the United States for decades, the epidemiological data on fibroid prevalence and risk factors are limited. self‐report, pelvic examinations, ultrasound or surgery), comparator group definitions, risk measures (e.g. Myomatous erythrocytosis syndrome: A case series, www.calteachersstudy.org/WebsiteGraphs.html#IDX2, In women with low BMI, current smoker vs never. Archives of Insect Biochemistry and Physiology. Immunological and clinical risk factors differ between recurrent implantation failure and recurrent miscarriage. Black race and 11 other factors affect uterine fibroid risk. The incidence of … Data on UF incidence, prevalence and associated risk factors were extracted from 60 publications. Journal of Gynecology Obstetrics and Human Reproduction. Uterine fibroids may also have reproductive effects (eg, infertility, adverse pregnancy outcomes). Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Uterine fibroids (UFs) are the most common neoplasm affecting women that can cause significant morbidity and may adversely impact fertility. Topics ranged from molecular techniques for mapping uterine fibroid cells to the use of green tea extract as a potential treatment. Feasibility of quantitative MR-perfusion imaging to monitor treatment response after uterine artery embolization (UAE) in symptomatic uterus fibroids. Uterine leiomyomata, commonly called fibroids, are the leading indication for hysterectomy in the United States. Using this criterion, 11 other factors were identified. Given the hormonal dependence of fibroids, most earlier studies focused on reproductive or hormonal factors. Results of the German Cohort Study on Women's Health, Risk of benign gynecologic tumors in relation to prenatal diethylstilbestrol exposure, Association of physical activity with development of uterine leiomyoma, Age‐related prevalence of sonographicaly confirmed uterine myomas, Risk factors for self‐reported uterine fibroids: a case‐control study, The incidence of uterine leiomyoma and other pelvic ultrasonographic findings in 2,034 consecutive women in a north London hospital, Protective effect of depot‐medroxyprogesterone acetate on surgically treated uterine leiomyomas: a multicentre case‐control study, Use of oral contraceptives and uterine fibroids: results from a case‐control study, Familial aggregation of uterine myomas in Japanese women, Relationship between metabolic syndrome and uterine leiomyomas: a case‐control study, Environmental exposure and risk of uterine leiomyoma: an epidemiologic survey, Genomics of uterine leiomyomas: insights from high‐throughput sequencing, Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers, Beneficial effects of nicotine and cigarette smoking: the real, the possible and the spurious, Functional hypothalamic amenorrhea and its influence on women's health, Uterine leiomyomas: mechanisms of tumorigenesis. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. For risk factors that were stratified by intervals (e.g. J Obstet Gynaecol Can. Epub 2017 Oct 1. In our systematic review of the epidemiology of UFs, we found wide variations in both the methodology and quality of the 60 selected studies, and also in the epidemiological data they report, with UF incidence ranging between 217 and 3745 cases per 100 000 women‐years and UF prevalence ranging between 4.5% and 68.6%. Journal of Assisted Reproduction and Genetics. Their prevalence usually is estimated at 30-40%, but may reach up to 70-80% in predisposed groups of women. Black race was the only factor that was recurrently reported to increase UF risk, by two–threefold compared with white race. This evaluation reveals the important risk factors to be age, premenopausal state, hypertension, family history, time since last birth, and food additive and soybean milk consumption. Bold values indicates reported magnitude of risk and protective factors compared with race. International Journal of Molecular Sciences. Unusual presentation of parasitic leiomyoma; a tale of twists and turns. AU - Wise, Lauren A. 10–14 Black women experience fibroids at an earlier age, have more severe symptoms, 10,15 and increased disease burden 15,16; however, less is known about other minorities, including Hispanic women. Most studies on UF epidemiology published before the mid‐1990s were based on diagnosis by pathological examination of surgical specimens.30 These older data therefore represent a population of highly selected patients who required hysterectomy, who may constitute only 10–30% of women with ultrasound evidence of UFs.43, 44 The development and widespread use of ultrasonography for UF detection since the mid‐1990s has expanded the epidemiological data on UFs to represent a wider population. After manual screening of titles and abstracts, 82 publications remained. Efficacy and safety of vilaprisan in women with uterine fibroids: Data from the phase 2b randomized controlled trial ASTEROID 2. In all four studies, black women were found to have a two–threefold greater risk of developing UFs than white women (Figure 3A; Table 1);27, 44, 48, 54 the lower boundary of the 95% CI of the risk (black versus white) was 1.69 or higher in all four studies. For some, this may be a sign of uterine fibroids, or myomas or leiyomyomas, which are noncancerous growths that develop in or around the uterus. Treatment of patients with uterine myoma in the period of menopausal transition. Relugolix, a novel oral gonadotropin-releasing hormone antagonist, in the treatment of pain symptoms associated with uterine fibroids: a randomized, placebo-controlled, phase 3 study in Japanese women. Clinical Pharmacology at the Intersection of Women's Health and Regulation: Drug Development Considerations for Uterine Fibroids. … The objectives of this review are to comprehensively survey the epidemiological data on UFs to describe their incidence and prevalence, and to examine trends in the epidemiology of UFs according to region. Uterine fibroids: from observational epidemiology to clinical management. To examine UF epidemiology and to evaluate the relative strengths of putative risk factors. These include age, race, endogenous and exogenous hormonal factors, obesity, uterine infection, and lifestyle (diet, caffeine and alcohol consumption, physical activity, stress, and smoking). National trends and determinants of hospitalization for uterine leiomyomas – Portuguese public database analysis from 2000 to 2015. Although many studies on the epidemiology of UFs have been published, reports of the incidence and prevalence of UFs vary widely depending on the method of diagnosis and the population studied; for example, estimates of the incidence of UFs range from 5.4% to 77% of women of reproductive age.2, 33-38 Furthermore, many different risk factors have been associated with the development of UFs, including biological, demographic, reproductive and lifestyle factors.26, 39-41 The true incidence and prevalence of UFs, and thus their global impact on women's health, and the role of putative risk factors, are therefore currently unknown. The Journal of Clinical Endocrinology & Metabolism. Dependent. Vitamin D as an effective treatment in human uterine leiomyomas independent of mediator complex subunit 12 mutation. Chapter 1. This site needs JavaScript to work properly. Over half the studies relied on self‐report and may therefore have been affected by recall bias. Tweetable abstract: 2008 Aug;22(4):571-88. doi: 10.1016/j.bpobgyn.2008.04.002. NIH Sociodemographic and substance use characteristics associated with typologies and composition of social support networks among youth experiencing homelessness in Los Angeles, USA. Incidence, aetiology and epidemiology of uterine fibroids. Updates and Controversies of Robotic-Assisted Surgery in Gynecologic Surgery. 2020 Dec 19;12(12):3839. doi: 10.3390/cancers12123839. Non-hormonal mediators of uterine fibroid growth. Evaluation of the incidence or prevalence of UFs was not the primary objective of most of the included studies, but they were reported in 51 of them. Mehine M, Khamaiseh S, Ahvenainen T, Heikkinen T, Äyräväinen A, Pakarinen P, Härkki P, Pasanen A, Bützow R, Vahteristo P. Cancers (Basel). Over half the studies (60%; 36/60) relied on self‐report and may therefore have been subject to recall bias. Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women. Mass spectrometry imaging: An emerging technology for the analysis of metabolites in insects. Examining Disparities in Route of Surgery and Postoperative Complications in Black Race and Hysterectomy. Journal of Community Hospital Internal Medicine Perspectives. Quality of ultrasonography reporting and factors associated with selection of imaging modality for uterine fibroids in Canada: results from a prospective cohort registry. years of oral contraceptive use in Marshall et al., 199846), only the significant intervals with Ptrend < 0.05 are included (Table S1).  |  In addition to studying the latest in diagnosis and treatment, Mayo Clinic doctors are conducting research in the epidemiology, economics and genetics of fibroids, as well as trying to develop prevention strategies. The basic science of uterine fibroids — benign tumors that grow in the uterus and cause an array of health problems — drew researchers from as far away as Spain to a scientific symposium Feb. 28 at NIEHS. Deep Dyspareunia: Review of Pathophysiology and Proposed Future Research Priorities. Uterine leiomyomata, also known as fibroids, are the leading indication for hysterectomy in the United States. A final data check was performed before data analysis. Validation of a menstrual pictogram and a daily bleeding diary for assessment of uterine fibroid treatment efficacy in clinical studies. 2011 Jun;20(6):915-22. doi: 10.1089/jwh.2009.1782. This higher incidence is, however, likely to be an overestimate reflecting the lack of diagnostic specificity of pelvic examination. Journal of Epidemiology and Community Health. Women with a positive family history of UFs were over three times more likely to have UFs than those without such a history (Table 1).77, In contrast, smoking, especially in women with low body mass index (BMI), was negatively associated with UF risk. Best Pract Res Clin Obstet Gynaecol. women undergoing investigations for possible UF symptoms). 2015 Feb;37(2):157-178. doi: 10.1016/S1701-2163(15)30338-8. Office-based Approach to Evaluation and Management of Abnormal Uterine Bleeding. international or local populations with different racial compositions, women undergoing screening or treatment, or survey respondents), diagnostic methods used (e.g. Uterine fibroids occur in about 70% of women. In the studies that reported the lowest incidences, UF diagnoses were based on self‐report or were confirmed by surgery.48, 71, 72 Most studies, reporting a wide range of incidences from 845 to 3745 cases per 100 000 women‐years, were based on self‐reports of a physician‐made diagnosis after ultrasound or hysterectomy.50, 66 UF incidence was reported to be higher when pelvic examination was included as a diagnostic method than when only ultrasound or hysterectomy was used (Figure 1A, B). Intra‐ and Inter‐Rater Agreement Describing Myometrial Lesions Using Morphologic Uterus Sonographic Assessment: A Pilot Study. Please enable it to take advantage of the complete set of features! Four women, for women: Caribbean diaspora artists reimag(in)ing the fine art canon. Age, premenopausal state, hypertension, family history, time since last birth, and food additive and soybean milk consumption increased UF risk; use of oral contraceptives or the injectable contraceptive depot medroxyprogesterone acetate, smoking in women with low body mass index and parity reduced UF risk. Despite the prevalence and significant impact of fibroids, public awareness about the condition is extremely low. Keywords: 4 Both estrogen and … Package inserts of oral contraceptives in Italy, Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound‐screening study, Hair relaxer use and risk of uterine leiomyomata in African‐American women, Cervical neoplasia‐related factors and decreased prevalence of uterine fibroids among a cohort of African American women, Heritability and risk factors of uterine fibroids – the Finnish Twin Cohort study, The burden of uterine fibroids in five European countries, Prevalence of self‐reported medical diagnosis of uterine leiomyomas in a Brazilian population: demographic and socioeconomic patterns in the pro‐saude study, Uterine fibroids: a ten‐year clinical review in Ilorin, Nigeria, Management of uterine fibroids in Enugu, Nigeria, Myomectomy at the Federal Medical Centre Gombe, Uterine leiomyoma at the surgical department of the Teaching Hospital of Dakar, Report of 140 cases operated in two years, The relationship between thyroid nodules and uterine fibroids, Association of intakes of fat, dietary fibre, soya isoflavones and alcohol with uterine fibroids in Japanese women, Population‐based case‐control study on risk factors of uterine myomas, Incidence and characteristics of uterine leiomyomas with FDG uptake, Self‐report versus ultrasound measurement of uterine fibroid status, Association of hypertension, hyperglycemia, hyperlipemia with the risk of uterine leiomyomata for female staffs in railway system, Epidemiological data for uterine fibroids in France in 2010‐2012 in medical center – analysis from the French DRG‐based information system (PMSI). Though most women with fibroids are asymptomatic, approximately 30% of them will present with severe symptoms which can include abnormal uterine bleeding, anemia, pelvic … The important protective factors were oral or injectable contraceptive use, smoking in women with low BMI and parity. The use of pelvic examination is likely to result in an overestimation of UF incidence as it is not a specific or sensitive test. Uterine artery embolization versus surgical treatment in patients with symptomatic uterine fibroids: Protocol for a systematic review and meta-analysis of individual participant data. Black race was the only factor that was recurrently reported to increase UF risk, by two-threefold compared with white race. Addressing heterogenous outcomes in uterine fibroid research: a call to action. Epub 2020 Sep 19. 2017 Apr 11;17(1):28. doi: 10.1186/s12905-017-0386-y. Uterine-Artery Embolization or Myomectomy for Uterine Fibroids. In addition, we have evaluated the relative strengths of over 30 factors reported to have a significant effect on UF risk and identified black race as the only factor consistently reported to increase UF risk, and 11 other factors that affect it to a similar or greater magnitude. The Evolving Role of Natural Compounds in the Medical Treatment of Uterine Fibroids. Epidemiology and management of uterine fibroids. AU - Laughlin-Tommaso, Shannon K. PY - 2016. Despite the morbidity and high medical costs associated with fibroids, there has been little epidemiologic study of this condition. Wide ranges were reported in both UF incidence (217-3745 cases per 100 000 women-years) and prevalence (4.5-68.6%), depending on study populations and diagnostic methods. High soy isoflavone or soy-based food intake during infancy and in adulthood is associated with an increased risk of uterine fibroids in premenopausal women: a meta-analysis. Comparing Perioperative Outcomes of Uterine Artery Embolization and Hysterectomy in Insurer and Demographically Diverse Populations: A Retrospective, Multi-Center Database Study. European Journal of Obstetrics & Gynecology and Reproductive Biology. CONCLUSION: We found a decreasing trend of new uterine fibroid diagnoses among predominantly symptomatic women ages 18-65 years in a recent 10-year interval. Papers that presented no data on incidence or prevalence of UFs or risk factors for UFs, epidemiological studies focused on other diseases or specific patient populations, randomised controlled trials, animal and in vitro studies, case studies, review, editorials and letters were excluded. Only one study specifically described women with asymptomatic UFs; the rest did not distinguish between symptomatic and asymptomatic UFs. Journal of Ayurveda and Integrative Medicine. Familial predisposition to uterine leiomyoma: searching for genetic factors that increase the risk of leyomyoma development. Black race and 11 other factors affect uterine fibroid risk. Role of Hormones in Common Benign Uterine Lesions: Endometrial Polyps, Leiomyomas, and Adenomyosis. Objectives: CC conducted the database searches and extracted the data; CC and RAG drafted the manuscript. Pavone D, Clemenza S, Sorbi F, Fambrini M, Petraglia F. Best Pract Res Clin Obstet Gynaecol. Full disclosure of interests available to view online as supporting information. ... leading to anemia, urinary tract infections, or kidney damage. The risk factor with the greatest magnitude was age, which was found to increase the risk of UFs by up to approximately tenfold. Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the uterus. Atypical uterine myoma in young women: diagnostics, treatment, rehabilitation. The true incidence and prevalence of uterine fibroids in the general female population are unknown because the condition is frequently asymptomatic and therefore not identified. There was a marked difference in UF incidence between racial groups, confirming that UFs are much more common in black than in white women (Figure 1B). Owing to the large number of risk factors discussed in the selected studies, here we focus on those risk factors for which the magnitude of the effect was approximately the same as or greater than the effect of race (Table 1; i.e. BMI, body mass index; CI, confidence interval; DMPA, depot medroxyprogesterone acetate; IRR, incidence rate ratio; OR, odds ratio; RR, relative risk; UFs, uterine fibroids. Selection criteria: 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). This finding was due, perhaps in part, to secular trends of decreasing hysterectomies. 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